Chemotherapy induced adverse drug reactions(ADR) in cervical cancer patients have been retrospectively from June 1989 to July 1991 at Kangnam St. Mary¢¥s Hospital. The used protocols are A(Cis, 5-Fu) : 65.7%, B(cis, VP-16) : 1.9%, C(Cis, Bleo, VBLV) : 18.5%, D(Cis, VBLV) : 7.4%. The kinds of adverse reaction are GI disturbance 75.3%, bone marrow suppression 29.2%, neurotoxicity 24.1%, hypersensitivity 23.8%, electrolyte disturbance 11.9%, kidney toxicity 0.9%, and the others 9.2%. Each patient experienced 2 kinds of ADR in average during the chemotherapy. The frequency of ADRs in accordance with the protocol was bone marrow suppression : B> D> A> C (P=0.079) : electrolyte disturbance : D> B> C> A(p+0.004) : hypersensitivity : C> B> D> A (P=0.000).
There was no correlation between the individual manifestation of ADRs and the protocols(r??o).
Only the frequency of the electrolyte disturbance was increased as the cycle was repeated (P=0.063). There was no correlation between the individual manifestation of ADRs and the cycle(r??o.) In order to treat the ADRs lorazepam, diazepam, haloperidol, metoclopramide, domperidone, diphenhydramin, dexamethason for N/V, transfusion for anemia and thrombocytopenia, antibiotics and leukotrofina for leucopenia, triazolam, flurazepam, diazepam for insomnia had been used.
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